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Quasi-irreversible inhibitor : ウィキペディア英語版 | Quasi-irreversible inhibitor For acetylcholinesterase (AChE), quasi-irreversible inhibitors are those that rapidly phosphorylate AChE. A subsequent internal dealkylation reaction may then occur, which, according to X-ray crystallography data, is suggestive of covalent bond formation. The newly formed OP-enzyme conjugate is as a result permanently deactivated. Historically, irreversible acetylcholinesterase inhibitors have been used as insecticides and chemical weapons. ==See also==
*Reversible inhibitors *Monoamine oxidase inhibitors *Enzyme inhibitor
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Quasi-irreversible inhibitor」の詳細全文を読む
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